Why the study?
Antemortem diagnosis of cardiac metastasis from melanoma has historically been uncommon, but improved imaging now allows early and accurate detection.
Case Report (n=1)
No
This case highlights the importance of multimodality imaging for the rare antemortem diagnosis of cardiac melanoma metastases and demonstrates the efficacy of targeted immunotherapy in achieving disease stability.
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Supports potential role of immunotherapy in cardiac melanoma metastases; leaves open need for prospective validation.
Melanoma is considered a masquerader of many diseases owing to its potential to metastasize to many organs. Several malignancies can metastasize to the heart including malignant melanoma. Historically, antemortem diagnosis of cardiac involvement of melanoma is not common, but with significant improvement in imaging modalities, the diagnosis can now be made early and accurately, aiding in treatment and improved survival. We present a case of a 36-year-old man with brief neurological symptoms and subsequent diagnosis of cerebrovascular accident (CVA). Cardiac imaging revealed incidental findings of right and left ventricular masses and lymph node biopsy, confirming metastatic melanoma. Cardioembolic etiology was suspected for his CVA. Prompt immunotherapy was initiated with improvement in his clinical condition.
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Kotaru et al. (2023) conducted a case report in Melanoma with cardiac metastasis (n=1). Nivolumab and ipilimumab was evaluated.
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