Why the study?
Metastatic melanoma can involve the heart and cause ventricular arrhythmia, but reports of this presentation are rare and treatment outcomes have evolved with new therapies.
Case Report (n=1)
Metastatic melanoma with cardiac involvement can present as ventricular arrhythmia and may be successfully managed with contemporary immune checkpoint inhibitors and targeted therapy.
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May support multimodality therapy for rare cardiac melanoma metastases; hypothesis-generating and requires prospective validation before practice change.
Melanoma is a highly aggressive disease with the risk of developing metastasis to virtually all organs including the heart, which can manifest as arrhythmia, right ventricular obstruction, heart failure, or pericardial effusion. Only a few reports are found in the literature of metastatic melanoma, causing ventricular arrhythmia. Prior to the advent of contemporary therapies, cardiac metastases implied a very poor prognosis. The use of immune checkpoint inhibitors and targeted therapy has greatly improved survival outcomes of metastatic melanoma. Aggressive therapy of cardiac metastasis including cardiac surgery can yield good outcomes. We present a case of a 57-year old gentleman with metastatic melanoma and cardiac involvement who initially presented as a ventricular arrhythmia and was successfully treated with immune checkpoint inhibitors and targeted therapy.
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Babar et al. (2020) conducted a case report in Metastatic melanoma with cardiac involvement (n=1). Surgical resection and immunotherapy (ipilimumab and nivolumab) was evaluated on Resolution of metastatic disease.
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