Key result
Cardiac metastasis in melanoma is frequently occult and carries a poor prognosis despite newer therapies.
Why the study?
Cardiac involvement in melanoma is clinically uncommon but presents significant diagnostic and therapeutic challenges due to its often silent course and nonspecific manifestations.
This review highlights the diagnostic and therapeutic challenges of melanoma-related cardiac metastases, emphasizing the role of advanced imaging for early detection and acknowledging poor prognosis despite advances in systemic therapies.
Answers are grounded in this paper and cite their sources.
May prompt earlier cardiac imaging for symptomatic melanoma patients; leaves open optimal screening strategies in prospective studies.
Cardiac involvement in melanoma, while clinically uncommon, presents significant diagnostic and therapeutic challenges due to its often silent course and nonspecific manifestations. Melanoma, a highly metastatic skin cancer, can spread to the heart, often remaining asymptomatic until advanced stages, when it may cause nonspecific symptoms such as chest pain and arrhythmias. This review explores the epidemiology, pathophysiology, and clinical manifestations of melanoma-related cardiac metastases, emphasizing the importance of advanced imaging techniques for early detection. It also discusses current management strategies, including immunotherapy and targeted therapies, which have improved survival outcomes. However, despite these advances, the prognosis for patients with cardiac metastases remains poor, highlighting the need for further research into more effective treatments.
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Bendayan et al. (2026) conducted a review in Melanoma with cardiac involvement. Cardiac involvement in melanoma is often asymptomatic until advanced stages and carries a poor prognosis despite advances in immunotherapy and targeted therapies.
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