Why the study?
Does intravenous fenoldopam mesylate reduce blood pressure as effectively as sodium nitroprusside in patients with severe hypertension or hypertensive crisis?
Population
Patients with severe hypertension or in hypertensive crisis
Comparison
Intravenous infusion of fenoldopam mesylate vs Intravenous infusion of sodium nitroprusside
Design
Other, open-label
Follow-up
2 days
Authors
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Fenoldopam mesylate offers a comparable option to nitroprusside for severe hypertension; confirms equivalent efficacy in this RCT.
Does intravenous fenoldopam mesylate reduce blood pressure as effectively as sodium nitroprusside in patients with severe hypertension or hypertensive crisis?
Intravenous fenoldopam is as effective as sodium nitroprusside for controlling severe hypertension and may be preferable in patients with decreased renal function due to the risk of thiocyanate toxicity with nitroprusside.
Reisin et al. (1990) studied this question.