April 1, 1989Archives of Internal Medicine
Comparative Renal Effects of Intravenous Administration of Fenoldopam Mesylate and Sodium Nitroprusside in Patients With Severe Hypertension
Why the study?
Does intravenous fenoldopam mesylate improve diuresis and natriuresis compared to sodium nitroprusside in patients with severe hypertension?
Population
11 patients with severe hypertension (supine BP, 168/124 to 252/135 mm Hg)
Comparison
Intravenous fenoldopam mesylate vs Intravenous sodium nitroprusside
Design
RCT, Randomized, Open-label
Follow-up
2 hours of treatment and 2 hours post-treatment
Authors
Discussion
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Member takes
Implication
Fenoldopam may be preferred over nitroprusside when diuresis is needed in severe hypertension; extends RCT evidence for differential renal effects during BP reduction.
Structured PICO
Does intravenous fenoldopam mesylate improve diuresis and natriuresis compared to sodium nitroprusside in patients with severe hypertension?
P
Population
11 patients with severe hypertension (supine BP, 168/124 to 252/135 mm Hg)
I
Intervention
Intravenous fenoldopam mesylate
C
Comparator
Intravenous sodium nitroprusside
O
Outcome
Renal effects including clearance of urea and creatinine, excretion of sodium, potassium, and calcium, urinary flow, and net fluid balancesurrogate
In patients with severe hypertension, acute BP reduction with fenoldopam induces diuresis and natriuresis, unlike nitroprusside which causes moderate volume expansion.
Cite This Study
William B. White (1989) studied this question.