What does this research mean for the field?

Intravenous fenoldopam is as effective as nitroprusside in safely lowering blood pressure in severe hypertension, but provides additional beneficial renal effects including increased urinary flow, sodium excretion, and creatinine clearance. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 1990CirculationOpen Access

Renal and hemodynamic effects of intravenous fenoldopam versus nitroprusside in severe hypertension.

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Why the study?

Does intravenous fenoldopam improve renal parameters compared to nitroprusside in patients with severe hypertension?

Population

28 patients with severe hypertension, most presenting with acute target organ damage, average age 49 +/- 3…

Comparison

Intravenous fenoldopam mesylate vs Intravenous sodium nitroprusside

Design

Cohort

Authors

WEW.J. ElliottGeneral / Preventive / Lipids RWRoy R. WeberUniversity of Chicago KNK. S. NelsonJohns Hopkins University Applied Physics Laboratory

Discussion

Member takes

Implication

May favor fenoldopam for renal preservation in severe hypertension; hypothesis-generating and requires RCT confirmation.

Structured PICO

Does intravenous fenoldopam improve renal parameters compared to nitroprusside in patients with severe hypertension?

Population

28 patients with severe hypertension (average blood pressure 219/137 mm Hg), most presenting with acute target organ damage, average age 49 +/- 3 years, 18 male, 26 black.

Intervention

Intravenous fenoldopam mesylate

Comparator

Intravenous sodium nitroprusside

Outcome

Renal and hemodynamic effects (blood pressure, urinary flow, sodium excretion, and creatinine clearance)surrogate

Intravenous fenoldopam effectively lowers blood pressure in severe hypertension while providing additional salutary renal effects compared to nitroprusside.

Cite This Study

Elliott et al. (1990) studied this question.

synapsesocial.com/papers/6a1c1fc4ea84844e355f7aae https://doi.org/10.1161/01.cir.81.3.970

Topics

Hypertension management

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Renal and hemodynamic effects of intravenous fenoldopam versus nitroprusside in severe hypertension.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Renal and hemodynamic effects of intravenous fenoldopam versus nitroprusside in severe hypertension.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider