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April 1, 1969Circulation

Digoxin Metabolism in the Elderly

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Why the study?

Does advanced age affect the metabolism and clearance of intravenous digoxin?

Population

14 men, including 5 elderly men and 9 young men.

Comparison

Tritiated digoxin 0.5 mg administered… vs Young men receiving the same dose of tritiated…

Design

Cohort

Follow-up

Not explicitly stated (measured beyond 24 hours)

Authors

GEGordon A. EwyGKGeeta KapadiaLYLinda L. Yao

Discussion

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Overview

Supports cautious digoxin dosing in elderly; leaves open prospective outcome validation.

Structured PICO

Does advanced age affect the metabolism and clearance of intravenous digoxin?

P
Population
14 men, including 5 elderly men (mean age 77 years, not in congestive heart failure) and 9 young men (mean age 27 years).
I
Intervention
Tritiated digoxin 0.5 mg administered intravenously.
C
Comparator
Young men (mean age 27 years) receiving the same dose of tritiated digoxin.
O
Outcome
Digoxin clearance, blood concentrations, and blood half-life.surrogate

Elderly patients exhibit reduced digoxin clearance and a longer half-life due to diminished urinary excretion and smaller body size, highlighting the need for age-adjusted dosing.

Cite This Study

Ewy et al. (1969) studied this question.

synapsesocial.com/papers/6a1c6feae2119f9cbea153c5https://doi.org/10.1161/01.cir.39.4.449
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