Triggered activity as a mechanism for inherited ventricular arrhythmias in German shepherd dogs
Population
Cardiac Purkinje fibers from German shepherd dogs with an inherited predisposition to sudden death and…
Comparison
In vitro superfusion with normal Tyrode… vs Purkinje fibers from unaffected dogs
Design
Preclinical
Authors
Discussion
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Implication
Supports Purkinje EAD-triggered activity as mechanism in this canine SCD model; leaves open human translation.
Structured PICO
P
Population
Cardiac Purkinje fibers from German shepherd dogs with an inherited predisposition to sudden death (affected, n=7) and unaffected dogs (n=13)
I
Intervention
In vitro superfusion with normal Tyrode solution, overdrive pacing, and pharmacological agents (phenylephrine, epinephrine, isoproterenol)
C
Comparator
Purkinje fibers from unaffected dogs
O
Outcome
Occurrence of early afterdepolarizations and triggered activitysurrogate
Early afterdepolarization-induced triggered activity in Purkinje fibers is the likely mechanism for inherited ventricular arrhythmias in this canine model of sudden death.
Cite This Study
Gilmour et al. (1996) studied this question.