Population
German shepherd dogs with inherited ventricular arrhythmias and sudden death and normal control dogs
Comparison
Assessment of beta-adrenergic receptor effector… vs Normal dogs and normally innervated regions of…
Design
Preclinical
Authors
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Suggests regional beta-adrenergic hypersensitivity as potential target; leaves open translation from this canine model to human arrhythmias.
Inherited ventricular arrhythmias in this canine model are associated with abnormal beta-adrenergic signal transduction in regions with reduced sympathetic innervation.
Eugene A. Sosunov (1999) studied this question.
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