Key result
Alpha-adrenergic stimulation with phenylephrine exacerbated arrhythmias in afflicted dogs by decreasing IK1 and increasing the arrhythmogenic trigger, while leaving the substrate unchanged.
Population
German shepherd dogs with inherited arrhythmias and sudden death (afflicted) and unafflicted dogs
Comparison
Phenylephrine (10(-9)-10(-5) M) vs Unafflicted dogs and baseline conditions
Design
Preclinical
Authors
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May heighten arrhythmia risk via IK1 reduction in susceptible patients; hypothesis-generating in canine models, requires human validation.
Alpha-adrenergic stimulation exacerbates ventricular arrhythmias in a canine model of inherited sudden death by increasing the arrhythmogenic trigger via a decrease in IK1, without altering the repolarization substrate.
Eugene A. Sosunov (2004) studied Inherited arrhythmias and sudden death. Phenylephrine vs. Unafflicted dogs / baseline was evaluated on Early afterdepolarizations (EADs), membrane potential, and IK1 current. Alpha-adrenergic stimulation with phenylephrine exacerbated arrhythmias in afflicted dogs by decreasing IK1 and increasing the arrhythmogenic trigger, while leaving the substrate unchanged.
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