Why the study?
Does alpha-adrenergic stimulation with phenylephrine facilitate the development of ventricular arrhythmias in dogs with inherited sudden death?
Population
27 dogs (20 with an inherited predisposition to sudden death and 7 unaffected dogs)
Comparison
Phenylephrine, with or without pretreatment with… vs Unaffected dogs and baseline measurements
Design
Preclinical
Authors
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Does not inform alpha-agonist use in patients; leaves open mechanistic role and human translation in inherited sudden death.
Does alpha-adrenergic stimulation with phenylephrine facilitate the development of ventricular arrhythmias in dogs with inherited sudden death?
Alpha-adrenergic stimulation with phenylephrine increases ventricular arrhythmias in dogs with inherited sudden death through both reflex bradycardia and direct myocardial effects.
Möise et al. (1996) studied this question.
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