August 26, 2003Circulation

Heterogeneous Ventricular Repolarization Provides a Substrate for Arrhythmias in a German Shepherd Model of Spontaneous Arrhythmic Death

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Population

German shepherd dogs with inherited arrhythmias and sudden death and unafflicted dogs; single anteroseptal…

Comparison

Isoproterenol administration and… vs Unafflicted dogs and baseline

Design

Preclinical

Authors

MOMaria N. ObreztchikovaUniversity of Minnesota ESEugene A. SosunovMount Sinai Hospital EAEvgeny P. AnyukhovskyStony Brook University

Discussion

Member takes

Implication

Regional IKr/IKs heterogeneity may drive arrhythmogenesis in this canine model; leaves open human translation and therapeutic targeting.

Structured PICO

Population

German shepherd dogs with inherited arrhythmias and sudden death (afflicted) and unafflicted dogs; single anteroseptal and anterobasal left ventricular myocytes.

Intervention

Isoproterenol administration and electrophysiological assessment (microelectrode techniques, whole-cell voltage clamp)

Comparator

Unafflicted dogs and baseline (without isoproterenol)

Outcome

Action potential duration to 90% repolarization (APD) and repolarizing currents (IKr and IKs)surrogate

Spatial heterogeneity in the expression and catecholamine responsiveness of IKr and IKs contributes to the arrhythmogenic substrate in a canine model of inherited arrhythmias.

Cite This Study

Obreztchikova et al. (2003) studied this question.

synapsesocial.com/papers/6a711d5e439bab0cabc3751f https://doi.org/10.1161/01.cir.0000086461.86642.22

Topics

Ventricular arrhythmias

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