August 19, 1997Circulation
Heterogeneous Sympathetic Innervation in German Shepherd Dogs With Inherited Ventricular Arrhythmia and Sudden Cardiac Death
Population
11 German shepherd dogs with inherited spontaneous cardiac arrhythmias and associated sudden death and 4…
Comparison
Imaging of functional myocardial sympathetic… vs Unrelated healthy control dogs.
Design
Preclinical
Authors
Discussion
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Implication
Heterogeneous denervation correlates with VT in this model; leaves open relevance to human arrhythmogenesis.
Structured PICO
P
Population
11 German shepherd dogs with inherited spontaneous cardiac arrhythmias and associated sudden death (age 6 months to 6 years) and 4 unrelated 7-month-old German shepherd dogs as controls (total n=15).
I
Intervention
Imaging of functional myocardial sympathetic innervation and perfusion with [123I]metaiodobenzylguanidine (MIBG) and 201Tl, and immunocytochemical localization of tyrosine hydroxylase.
C
Comparator
Unrelated healthy control dogs.
O
Outcome
Distribution of functional myocardial sympathetic innervation and perfusion, and extent of denervation.surrogate
German shepherd dogs with inherited ventricular arrhythmias exhibit abnormal heterogeneous sympathetic innervation, with the extent of denervation correlating with the presence of ventricular tachycardia.
Cite This Study
Dae et al. (1997) studied this question.