Key result
Aging spontaneously hypertensive rats progressively developed features of HF-PEF, including impaired left ventricular relaxation, hypertrophy, increased BNP, and fibrosis.
Why the study?
Do aging spontaneously hypertensive rats develop features typical of human heart failure with preserved ejection fraction?
Do aging spontaneously hypertensive rats develop features typical of human heart failure with preserved ejection fraction?
Aging spontaneously hypertensive rats represent a pertinent preclinical model for studying heart failure with preserved ejection fraction.
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Supports aging SHR as HFpEF model; leaves open human translation and clinical relevance.
Marzak et al. (2014) studied Heart failure with preserved left-ventricular ejection fraction (HF-PEF). Spontaneously hypertensive rat (SHR) model vs. Normotensive controls (Wistar-Kyoto rats) was evaluated on Development of HF-PEF features (echocardiographic, hemodynamic, histological, and biomarker changes). Aging spontaneously hypertensive rats progressively developed features of HF-PEF, including impaired left ventricular relaxation, hypertrophy, increased BNP, and fibrosis.
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