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June 29, 2020BMC AnesthesiologyOpen Access

Intraoperative hypotension is associated with shortened overall survival after lung cancer surgery

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Why the study?

Intraoperative hypotension increases postoperative morbidity and mortality, but its association with worse long-term survival after cancer surgery remained unknown.

Does intraoperative hypotension reduce overall survival in patients undergoing lung cancer surgery?

Population

676 patients undergoing lung cancer surgery

Comparison

Intraoperative hyper- vs hypotension vs both vs neither

Design

Retrospective cohort study

Follow-up

Median duration of 5.2 years

Authors

WHWenwen HuangNanjing Agricultural UniversityWZWenzhi ZhuPeking UniversityDMDong-Liang MuOutcomes Research Consortium

Discussion

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Implication

Intraoperative hypotension may warrant vigilance in lung cancer surgery but should not yet change practice; extends short-term morbidity links to survival in observational data.

Structured PICO

Does intraoperative hypotension reduce overall survival in patients undergoing lung cancer surgery?

P
Population
515 adults (age ≥18 years) who received intrathoracic lung cancer surgery with confirmed pathological diagnosis and tracked intraoperative blood pressure, median age 61, 63.7% male, single-center in China.
I
Intervention
Intraoperative hypotension (defined as systolic blood pressure < 100 mmHg for ≥5 min).
C
Comparator
Patients with only intraoperative hypertension (systolic blood pressure > 140 mmHg for ≥5 min) or neither hyper- nor hypotension.
O
Outcome
Overall survival (duration from surgery to death of any cause)hard clinical

Intraoperative hypotension (SBP < 100 mmHg for ≥5 min) is associated with shortened overall survival in patients undergoing lung cancer surgery.

Limitations

  • Observational single-center nature
  • Binary definitions of intraoperative hypo- and hypertension without analyzing duration effects
  • Lack of precise data regarding pre- and intraoperative antihypertensive therapy
  • Lack of postoperative blood pressure data
  • Further analysis of a database from a similar patient cohort

Cite This Study

Huang et al. (2020) studied this question.

synapsesocial.com/papers/6a1cbfdd566b67b7d585dddahttps://doi.org/10.1186/s12871-020-01062-2

Topics

Hypertension management
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Also Consider

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