Why the study?
Do acute hypertension transients alter diastolic function and stiffness in patients with HFpEF compared to controls?
Population
39 patients with heart failure with preserved ejection fraction (HFpEF) and 20 controls
Comparison
Acute hypertension transients induced by… vs 20 controls undergoing the same protocol
Design
Cross-sectional
Authors
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Transient hypertension may worsen diastolic pressures in HFpEF; hypothesis-generating for matrix-targeted interventions, needs prospective trials.
Do acute hypertension transients alter diastolic function and stiffness in patients with HFpEF compared to controls?
Acute chamber stiffening is the primary mechanism for elevated late-diastolic pressures during acute hypertension in HFpEF patients, correlating with matrix remodeling.
Villar et al. (2017) studied this question.
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