Population
20-week-old ZSF1 obese rats model of HFpEF, healthy Wistar-Kyoto rats, and hypertensive ZSF1 lean control rats
Comparison
Suddenly imposed isovolumic afterload by swift… vs Baseline hemodynamics
Design
Preclinical
Authors
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Impaired relaxation may contribute to effort intolerance in HFpEF; leaves open translation from animal models to clinical practice.
In an experimental HFpEF model, delayed relaxation during pressure challenge contributes significantly to elevated end-diastolic pressures, suggesting a mechanism for effort intolerance.
Leite et al. (2015) studied this question.
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