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Enhances mechanistic understanding of pulmonary vascular remodeling in congenital heart disease; leaves open targeted therapeutic strategies.
. These changes, knownas pulmonary plexogenic arteriopathy, include increasedmuscularization, altered vasoconstrictive and impairedvasodilatatory responses in the arterial tree, andextensive extracellular matrix modulation (includingincreased collagen deposition and gradual occlusion ofthe small pulmonary arteries by intimal proliferationand fibrosis)
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Rudolphus Berger (2000) studied this question.
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