February 3, 2007Journal of Hypertension
Rates and determinants of reinitiating antihypertensive therapy after prolonged stoppage: a population-based study
Why the study?
What are the rates and determinants of reinitiating antihypertensive therapy after prolonged discontinuation in patients previously on blood pressure-lowering medication?
Population
18,357 patients who discontinued blood pressure-lowering treatment for at least 180 days in the PHARMO…
Design
Cohort
Follow-up
up to 6 years
Authors
Discussion
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Member takes
Implication
Reinitiation often follows CVD hospitalization; hypothesis-generating for adherence interventions but should not yet change practice.
Structured PICO
What are the rates and determinants of reinitiating antihypertensive therapy after prolonged discontinuation in patients previously on blood pressure-lowering medication?
P
Population
18,357 patients who discontinued blood pressure-lowering treatment for at least 180 days (from an initial cohort of 35,714 new users) in the PHARMO database in The Netherlands.
I
Intervention
Reinitiating antihypertensive therapy
O
Outcome
Reinitiation of blood pressure-lowering treatment
A majority of patients who discontinue antihypertensive therapy for prolonged periods eventually resume treatment, often triggered by cardiovascular events or other cardiovascular medication refills.
Cite This Study
Wijk et al. (2007) studied this question.