Why the study?
Hypertension involves abnormalities of cardiac output and systemic vascular resistance, but whether selecting antihypertensive therapy based on hemodynamic profiles improves blood pressure control more than standard care in real-world practice was untested.
Does an impedance cardiography (ICG) guided treatment strategy improve blood pressure reduction compared to standard care in adults with uncontrolled hypertension?
Population
102 adults with uncontrolled hypertension seeking outpatient care in Beijing, China
Comparison
Impedance cardiography guided treatment vs standard care
Design
Pilot single-center pragmatic randomized trial
Follow-up
4-12 weeks
Key result
An impedance cardiography-guided treatment strategy significantly reduced systolic blood pressure by 19.9 mmHg compared to a 12.0 mmHg reduction with standard care in patients with uncontrolled hypertension.
Authors
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Supports ICG-guided therapy for greater BP reductions in uncontrolled hypertension; extends evidence for hemodynamic tailoring in this pilot RCT.
RCT (n=102)
Single-blind
1:1
No
Does an impedance cardiography (ICG) guided treatment strategy improve blood pressure reduction compared to standard care in adults with uncontrolled hypertension?
Absolute Event Rate: 19.9% vs 12%
p-value: p=<0.001
An impedance cardiography-guided treatment strategy significantly improved systolic and diastolic blood pressure reductions compared to standard care in outpatients with uncontrolled hypertension.
Wang et al. (2021) conducted an RCT in Uncontrolled hypertension (n=102). Impedance cardiography (ICG) guided treatment strategy vs. Standard care was evaluated on Change in systolic blood pressure (SBP) from baseline (p=<0.001). An impedance cardiography-guided treatment strategy significantly reduced systolic blood pressure by 19.9 mmHg compared to a 12.0 mmHg reduction with standard care in patients with uncontrolled hypertension.