What does this research mean for the field?

Exercise training improves the endothelium-mediated vasodilatory capacity of collateral arteries following arterial occlusion, likely through the enhanced production of endothelium-derived hyperpolarizing factor(s). Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 2, 2010The Journal of PhysiologyOpen Access

Vasoresponsiveness of collateral vessels in the rat hindlimb: influence of training

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Why the study?

Does daily treadmill exercise improve the vasodilatory capacity of collateral arteries in rats with femoral artery occlusion?

Population

Rats exposed to surgical occlusion of the femoral artery

Comparison

Daily treadmill exercise training for 3 weeks vs Sedentary rats with femoral artery ligation

Design

Preclinical

Follow-up

3 weeks

Authors

PCPatrick N. ColleranUniversity of Liverpool ZLZeyi LiShanghai Jiao Tong University HYH. T. YangUniversity of Missouri

Discussion

Member takes

Implication

Supports exercise-enhanced collateral endothelial function in rat PAD models; leaves open translation to human therapy.

Structured PICO

Does daily treadmill exercise improve the vasodilatory capacity of collateral arteries in rats with femoral artery occlusion?

Population

Rats exposed to surgical occlusion of the femoral artery

Intervention

Daily treadmill exercise training for 3 weeks

Comparator

Sedentary rats with femoral artery ligation (non-occluded contralateral vessels served as normal control)

Outcome

Vasomotor properties of isolated peripheral collateral arteries (vasodilatory responses to acetylcholine, sodium nitroprusside, and flow; constrictor responses to phenylephrine)surrogate

Exercise training improves endothelium-mediated vasodilatory capacity of hindlimb collateral arteries in a rat model of peripheral arterial insufficiency.

Cite This Study

Colleran et al. (2010) studied this question.

synapsesocial.com/papers/6a1e874b09554abc3868e9c9 https://doi.org/10.1113/jphysiol.2009.186247

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Vasoresponsiveness of collateral vessels in the rat hindlimb: influence of training

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Vasoresponsiveness of collateral vessels in the rat hindlimb: influence of training

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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