Why the study?
Does prior exercise training improve NO-dependent collateral blood flow after acute arterial occlusion in rats?
Population
Adult male Sprague-Dawley rats (~325 g) subjected to acute bilateral femoral artery occlusion (n=58)
Comparison
Prior exercise training with or without NOS… vs Sedentary lifestyle with or without NOS blockade
Design
Preclinical
Follow-up
6 weeks (training period)
Authors
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Supports NO-dependent collateral flow with training in rats; hypothesis-generating for human peripheral artery disease.
Does prior exercise training improve NO-dependent collateral blood flow after acute arterial occlusion in rats?
Prior exercise training enhances collateral blood flow following acute arterial occlusion primarily through increased NO-dependent endothelium-mediated dilation.
Yang et al. (2002) studied this question.
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