Forearm beta adrenergic receptor-mediated vasodilation is impaired, without alteration of forearm norepinephrine spillover, in borderline hypertension.

Q: What does this research mean for the field?

Beta-adrenergic receptor-mediated vasodilation is impaired in borderline hypertension, and this impairment is not explained by increased local sympathetic activity. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Christoph Stein; Richard Alan Nelson; Robert Deegan; Hongbin He; Margaret Wood; A. J. J. Wood

doi:10.1172/jci118070

July 1, 1995Journal of Clinical InvestigationOpen Access

Forearm beta adrenergic receptor-mediated vasodilation is impaired, without alteration of forearm norepinephrine spillover, in borderline hypertension.

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Why the study?

Is beta adrenoceptor-mediated vasodilation impaired in subjects with borderline hypertension compared to normotensive controls?

Structured PICO

Is beta adrenoceptor-mediated vasodilation impaired in subjects with borderline hypertension compared to normotensive controls?

P

Population

21 subjects, comprising 8 with borderline hypertension (BHT) and 13 normotensive (NT) controls.

I

Intervention

Intraarterial administration of increasing doses of isoproterenol (up to 400 ng/min).

C

Comparator

Normotensive controls receiving the same intervention.

O

Outcome

Vasodilation (changes in forearm blood flow or forearm vascular resistance) measured by strain gauge plethysmography.surrogate

Beta adrenoceptor-mediated vasodilation is impaired early in the hypertensive disease process, independent of local sympathetic activity.

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Implication

Impaired beta-adrenoceptor vasodilation appears early in hypertension; extends observations from established disease independently of sympathetic activity.

Abstract

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Cite This Study

Stein et al. (1995) studied this question.

synapsesocial.com/papers/6a1e925144dc0a902547d2f2 https://doi.org/10.1172/jci118070

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Forearm beta adrenergic receptor-mediated vasodilation is impaired, without alteration of forearm norepinephrine spillover, in borderline hypertension.

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Forearm beta adrenergic receptor-mediated vasodilation is impaired, without alteration of forearm norepinephrine spillover, in borderline hypertension.

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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