Why the study?
Serotype O foot-and-mouth disease virus has the broadest worldwide distribution, which could be due to high virulence and transmissibility induced by high genetic diversity.
Answers are grounded in this paper and cite their sources.
Higher genetic diversity of type O FMDV increases virulence and transmissibility, explaining its global dominance.
Among the seven serotypes of FMDV, serotype O FMDV have the broadest distribution worldwide, which could be due to their high virulence and transmissibility induced by high genetic diversity. In this paper, we generated a single amino acid substitution FMDV variant with a high-fidelity polymerase associated with viral fitness, virulence, and transmissibility in a natural host. The results highlight that maintenance of viral population diversity is essential for interhost viral spread. This study provides evidence that higher genetic diversity of type O FMDV could increase both virulence and transmissibility, thus leading to their dominance in the global epidemic.
No takes yet. Share an insight, caveat, or question.
Li et al. (2020) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: