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June 1, 1978Circulation ResearchOpen Access

Whole body vascular reactivity during the development of deoxycorticosterone acetate hypertension in the pig.

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Why the study?

Does DOCA implantation alter whole body vascular reactivity to norepinephrine and angiotensin II during the development of hypertension in a pig model?

Population

Pigs, 8-12 weeks of age, subjected to unilateral nephrectomy and instrumented with an electromagnetic…

Comparison

Subcutaneous implantation of Silastic strips… vs Baseline response curves in the same…

Design

Preclinical

Follow-up

4 weeks

Authors

KBKathleen H. BerecekUniversity of IowaDBDavid F. BohrNHS Blood and Transplant

Discussion

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Implication

Supports vascular hyperreactivity as potential initiator in experimental hypertension; leaves open relevance to human disease.

Structured PICO

Does DOCA implantation alter whole body vascular reactivity to norepinephrine and angiotensin II during the development of hypertension in a pig model?

P
Population
Pigs, 8-12 weeks of age, subjected to unilateral nephrectomy and instrumented with an electromagnetic flowprobe on the ascending aorta and catheters in the aorta and thoracic vena cava.
I
Intervention
Subcutaneous implantation of Silastic strips impregnated with deoxycorticosterone acetate (DOCA) (100 mg/kg), with graded intravenous infusions of norepinephrine or angiotensin II given at intervals.
C
Comparator
Baseline (pre-DOCA) response curves in the same unanesthetized pigs.
O
Outcome
Changes in total peripheral resistance (calculated from mean arterial pressure and cardiac output) and vascular smooth muscle sensitivity to norepinephrine and angiotensin II.surrogate

In a pig model of DOCA-induced hypertension, increased systemic vascular reactivity to norepinephrine and angiotensin II coincides with the initial rise in arterial pressure, suggesting it may initiate the hypertensive process.

Cite This Study

Berecek et al. (1978) studied this question.

synapsesocial.com/papers/6a1ea5d6989adebfe89a6717https://doi.org/10.1161/01.res.42.6.764

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Background of Increased Flow Resistance and Vascular Reactivity in Spontaneously Hypertensive Rats1970 · 325 citations
  2. 2The Effect of Functionally Induced Changes of Wall/Lumen Ratio on the Vasoconstrictor Response to Standard Amounts of Vasoactive Agents1960 · 27 citations
  3. 3Effects of Immersion in Water and Changes in Intrathoracic Blood Volume on Lung Function in Man1976 · 29 citations
  4. 4Deoxycorticosterone Hypertension in the Pig1976 · 40 citations
  5. 5Central and peripheral adrenergic mechanisms in the development of deoxycorticosterone-saline hypertension in rats.1975 · 202 citations