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May 1, 1972Clinical Science

Vascular Reactivity in Post-Deoxycorticosterone Hypertension in Rats and its Relation to ‘Irreversible’ Hypertension in Man

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Why the study?

Does temporary administration of DOCA and saline alter vascular reactivity in rats compared to normotensive controls?

Population

Rats with post-deoxycorticosterone (DOCA) hypertension and normotensive controls

Comparison

Temporary administration of deoxycorticosterone… vs Normotensive controls

Design

Preclinical

Authors

LBLawrence J. BeilinGeneral / Preventive / LipidsGZG. ZiakasAristotle University of Thessaloniki

Discussion

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Implication

Hypothesis-generating for vascular remodeling sustaining hypertension after DOCA withdrawal in rats; does not inform clinical practice.

Structured PICO

Does temporary administration of DOCA and saline alter vascular reactivity in rats compared to normotensive controls?

P
Population
Rats with post-deoxycorticosterone (DOCA) hypertension and normotensive controls
I
Intervention
Temporary administration of deoxycorticosterone (DOCA) and saline
C
Comparator
Normotensive controls
O
Outcome
Vascular reactivity in the resistance bed of the isolated perfused rat tailsurrogate

Structural changes in resistance vessels resulting from hypertension may explain the persistence of elevated blood pressure after the initial cause is removed.

Cite This Study

Beilin et al. (1972) studied this question.

synapsesocial.com/papers/6a7e27f3fdb0e04bb5e97128https://doi.org/10.1042/cs0420579

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Peripheral neurogenic mechanisms in deoxycorticosterone acetate – salt hypertension in the rat1989 · 15 citations
  2. 2Histometric assessment of renal arterioles during DOCA and post-DOCA hypertension and hydralazine treatment in rats1989 · 5 citations
  3. 3Microvascular responses to endothelin in deoxycorticosterone acetate-salt hypertensive rats2000 · 15 citations
  4. 4Abnormal regulation of the sympathoadrenal system in deoxycorticosterone acetate – salt hypertensive rats1987 · 22 citations
  5. 5Whole body vascular reactivity during the development of deoxycorticosterone acetate hypertension in the pig.1978 · 99 citations