What does this research mean for the field?

Atrial natriuretic factor (ANF) binding to its receptor is strictly dependent on chloride concentration, which may serve as a feedback-control mechanism regulating renal sodium excretion. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 9, 2000Circulation ResearchOpen Access

Atrial Natriuretic Factor Binding to Its Receptor Is Dependent on Chloride Concentration

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Population

Purified recombinant hormone-binding domain of the ANF receptor and native receptor in bovine adrenocortical…

Comparison

Exposure to varying concentrations and types of… vs Different salt conditions

Design

Preclinical

Authors

KMKunio S. MisonoUniversity of Nevada, Reno

Discussion

Member takes

Implication

May indicate chloride modulates ANF-receptor effects on sodium excretion; leaves open relevance beyond this animal model.

Structured PICO

Population

Purified recombinant hormone-binding domain of the ANF receptor and native receptor in bovine adrenocortical membrane preparations

Intervention

Exposure to varying concentrations and types of salts (NaCl, KCl, NH4Cl, NaHCO3, CH3COONa, CH3COONH4)

Comparator

Different salt conditions (presence vs absence of chloride)

Outcome

ANF binding to its receptorsurrogate

ANF binding to its receptor requires chloride, suggesting a potential feedback-control mechanism regulating ANF-receptor action and renal sodium excretion.

Cite This Study

Kunio S. Misono (2000) studied this question.

synapsesocial.com/papers/6a1ec4aabf2a5d44faaf4bd9 https://doi.org/10.1161/01.res.86.11.1135

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Atrial Natriuretic Factor Binding to Its Receptor Is Dependent on Chloride Concentration

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Atrial Natriuretic Factor Binding to Its Receptor Is Dependent on Chloride Concentration

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider