What question did this study set out to answer?

To evaluate the functional responsiveness of carotid and aortic chemoreceptors to chemical stimuli and their respective roles in ventilatory reflex control in normal Wistar rats.

March 1, 1977Journal of Applied Physiology

Carotid and aortic chemoreceptor function in the rat

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Authors

HSHreday N. SapruRutgers, The State University of New Jersey AKAbbott J. KriegerLudwig-Maximilians-Universität München

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Implication

Experimental study reveals active carotid but absent functional aortic chemoreceptors in normal Wistar rats, indicating distinct peripheral arterial chemoreflex organization.

Key Points

To evaluate the functional responsiveness of carotid and aortic chemoreceptors to chemical stimuli and their respective roles in ventilatory reflex control in normal Wistar rats.
Administered sodium cyanide, lobeline HCl, and doxapram HCl at doses of 2–400 μg/kg into the external carotid artery and ascending aorta in normal Wistar rats.
Assessed respiratory stimulation before and after surgical section of the carotid sinus nerves.
Recorded electrical neural discharge rates directly from the carotid sinus nerve, aortic depressor nerve, and recurrent laryngeal nerve following chemical administration.
Intra-carotid administration of all three chemical agents significantly stimulated respiration and evoked marked increases in carotid sinus nerve electrical activity.
Ascending aorta injections produced attenuated respiratory responses that were entirely abolished after bilateral section of the carotid sinus nerves.
Chemical stimulants failed to elicit any increase in electrical activity in either the aortic depressor or recurrent laryngeal nerves, demonstrating the absence of functional aortic chemoreceptors.

Cite This Study

Sapru et al. (1977) studied this question.

synapsesocial.com/papers/6a1f36e1d09bc027e4832f77 https://doi.org/10.1152/jappl.1977.42.3.344

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Implication

Experimental study reveals active carotid but absent functional aortic chemoreceptors in normal Wistar rats, indicating distinct peripheral arterial chemoreflex organization.

Carotid and aortic chemoreceptor function in the rat

Discussion

Member takes

Implication

Key Points

Cite This Study

Carotid and aortic chemoreceptor function in the rat

Discussion

Member takes

Implication

Key Points

Cite This Study

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