Why the study?
Does intracarotid injection of sodium cyanide or dopamine alter internal intercostal muscle activity via carotid chemoreflexes in rabbits?
Does intracarotid injection of sodium cyanide or dopamine alter internal intercostal muscle activity via carotid chemoreflexes in rabbits?
Excitatory and inhibitory responses of internal intercostal muscle activity to intracarotid injections of sodium cyanide and dopamine are mainly mediated through carotid chemoreflexes in rabbits.
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Does not change clinical practice; leaves open translation of carotid chemoreflex effects on respiratory muscles to humans.
The effects of carotid chemoreceptor stimulating and depressing agents on internal intercostal muscle activity (IIMA) were studied before and after surgical denervation of the carotid sinus nerve (CSN) in the rabbit. An intracarotid injection of 30 micrograms of sodium cyanide (NaCN) during inspiration caused an increase in both IIMA and respiratory rate (RR). In contrast, intracarotid administration of 10 micrograms of dopamine (DA) during inspiration resulted in a decrease in both IIMA and RR. The NaCN- and DA-induced characteristic responses in IIMA were abolished by the section of the CSN. The results indicate that the excitatory and inhibitory responses of IIMA to intracarotid injections of NaCN and DA are mainly mediated through carotid chemoreflexes.
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Shigeji Matsumoto (1986) studied this question.
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