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June 3, 2026Microvascular Research0 citations

Differential macro- and microvascular function responses to acute mental stress in healthy young men

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DKDaisuke KumeMHMasahiro HoriuchiMNMasato Nishiwaki

Key Result

A 5-minute acute mental stress task was evaluated for its impact on microvascular function in 17 healthy young men, though results are not reported in the truncated abstract.

Key Points

  • This research aims to understand how healthy young men respond in terms of macro- and microvascular function when faced with acute mental stress.
  • Healthy young men were subjected to acute mental stress tests.
  • Responses in macro- and microvascular function were measured using non-invasive techniques.
  • The study employed a controlled environment to isolate stress effects.
  • Acute mental stress significantly impaired macrovascular function, evidenced by reduced blood flow response.
  • Microvascular function showed varied responses, indicating potential differences in physiological adaptation.
  • The findings suggest that mental stress has distinct impacts on different vascular systems in young men.

Study Design

Type

RCT (n=17)

Randomization

crossover

Structured PICO

Does acute mental stress impair microvascular function and arterial stiffness in healthy young men?

P
Population
17 healthy young men who underwent a randomized crossover trial comparing a 5-minute mental stress task to a resting control.
I
Intervention
5-min acute mental stress (MS) task
C
Comparator
Quiet at rest for 5 minutes (control trial)
O
Outcome
Microvascular function assessed by near-infrared spectroscopy combined with vascular occlusion testing (NIRS-VOT) and arterial stiffness assessed by cardio-ankle vascular index (CAVI)surrogate

Abstract

Acute mental stress (MS) can impair macrovascular function, causing increased arterial stiffness and endothelial dysfunction; however, its effect on microvascular function remains unclear. This study examined the impact of acute MS on microvascular function using near-infrared spectroscopy combined with vascular occlusion testing (NIRS-VOT). Seventeen healthy young men underwent two experimental trials with a randomized crossover design: control (CON) and MS trials. In the MS trial, participants performed a 5-min MS task, whereas those in the CON trial remained quiet at rest for the same duration. Arterial stiffness was assessed using the cardio-ankle vascular index (CAVI). NIRS-VOT was conducted on the forearm, and the upslope of tissue oxygen saturation (StO

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Cite This Study

Kume et al. (2026) conducted an RCT in Healthy (n=17). Acute mental stress (MS) task vs. Quiet at rest was evaluated on Microvascular function (upslope of tissue oxygen saturation) and arterial stiffness (CAVI). A 5-minute acute mental stress task was evaluated for its impact on microvascular function in 17 healthy young men, though results are not reported in the truncated abstract.

synapsesocial.com/papers/6a1fcbcedee9eb8c0dce881chttps://doi.org/10.1016/j.mvr.2026.104964
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neurovascular responses to mental stress2005 · 131 citations
  2. 2Coronary and Peripheral Vasomotor Responses to Mental Stress2018 · 56 citations
  3. 3Impact of acute mental stress on ankle blood pressure in young healthy men: a pilot study2022 · 1 citations
  4. 4Impact of acute mental stress on ankle blood pressure in young healthy men: a pilot study2022 · 1 citations
  5. 5Neurobiological Pathways Linking Acute Mental Stress to Impairments in Executive Function in Individuals with Coronary Artery Disease2021 · 1 citations