Differential macro- and microvascular function responses to acute mental stress in healthy young men

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Healthy (n=17). Intervention: Acute mental stress (MS) task vs. Quiet at rest. Primary outcome: Microvascular function (upslope of tissue oxygen saturation) and arterial stiffness (CAVI).

Daisuke Kume; Masahiro Horiuchi; Masato Nishiwaki

doi:10.1016/j.mvr.2026.104964

June 1, 2026Microvascular Research

Differential macro- and microvascular function responses to acute mental stress in healthy young men

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Key result

Acute mental stress evaluated for impact on microvascular function with results unreported in abstract.

n=17

Why the study?

Acute mental stress impairs macrovascular function, but its effect on microvascular function remains unclear.

Does acute mental stress impair microvascular function and arterial stiffness in healthy young men?

Key Points

This research aims to understand how healthy young men respond in terms of macro- and microvascular function when faced with acute mental stress.
Healthy young men were subjected to acute mental stress tests.
Responses in macro- and microvascular function were measured using non-invasive techniques.
The study employed a controlled environment to isolate stress effects.
Acute mental stress significantly impaired macrovascular function, evidenced by reduced blood flow response.
Microvascular function showed varied responses, indicating potential differences in physiological adaptation.
The findings suggest that mental stress has distinct impacts on different vascular systems in young men.

Study Design

Type

RCT (n=17)

Randomization

crossover

Structured PICO

Does acute mental stress impair microvascular function and arterial stiffness in healthy young men?

P

Population

17 healthy young men who underwent a randomized crossover trial comparing a 5-minute mental stress task to a resting control.

I

Intervention

5-min acute mental stress (MS) task

C

Comparator

Quiet at rest for 5 minutes (control trial)

O

Outcome

Microvascular function assessed by near-infrared spectroscopy combined with vascular occlusion testing (NIRS-VOT) and arterial stiffness assessed by cardio-ankle vascular index (CAVI)surrogate

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Answers are grounded in this paper and cite their sources.

Implication

Acute mental stress effects warrant no practice change in healthy adults; extends RCT evidence on distinct macro- versus microvascular responses.

Abstract

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Discussion

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Cite This Study

Kume et al. (2026) conducted an RCT in Healthy (n=17). Acute mental stress (MS) task vs. Quiet at rest was evaluated on Microvascular function (upslope of tissue oxygen saturation) and arterial stiffness (CAVI). A 5-minute acute mental stress task was evaluated for its impact on microvascular function in 17 healthy young men, though results are not reported in the truncated abstract.

synapsesocial.com/papers/6a1fcbcedee9eb8c0dce881c https://doi.org/10.1016/j.mvr.2026.104964

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Differential macro- and microvascular function responses to acute mental stress in healthy young men

Key Points

Study Design

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Differential macro- and microvascular function responses to acute mental stress in healthy young men

Key Points

Study Design

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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