Key result
The DD genotype of ACE and TT genotype of ACE2 were significantly associated with essential hypertension in females, while the T allele of ACE2 and alcohol consumption were associated in males.
Why the study?
Are ACE I/D and ACE2 rs2106809 polymorphisms associated with essential hypertension in the population of Odisha, India?
Case-Control (n=520)
Are ACE I/D and ACE2 rs2106809 polymorphisms associated with essential hypertension in the population of Odisha, India?
ACE I/D and ACE2 rs2106809 polymorphisms are associated with essential hypertension in the population of Odisha, India, with notable sex-specific differences.
Answers are grounded in this paper and cite their sources.
May inform sex-specific hypertension risk assessment in India; extends genetic association data but remains hypothesis-generating.
BACKGROUND: Hypertension is a serious health issue worldwide and essential hypertension, which includes 90-95% of the cases, is influenced by both genetic and environmental factors. Identification of these factors may help in control of this disease. The Insertion/Deletion (I/D) polymorphism in Angiotensin-Converting Enzyme (ACE) gene and rs2106809 (C > T) polymorphism in Angiotensin-Converting Enzyme 2 (ACE2) gene have been reported to be associated with essential hypertension in different populations. AIM: To investigate the association of ACE I/D and ACE2 rs2106809 polymorphisms with essential hypertension in the population of Odisha, an eastern Indian state. SUBJECTS AND METHODS: A total of 246 hypertensives (159 males and 87 females) and 274 normotensives (158 males and 116 females) were enrolled in the study. Detailed anthropometric data, tobacco, alcohol and food habits were recorded and 2 ml of venous blood was collected for biochemical and genetic analysis. RESULTS: The DD genotype of ACE and TT genotype of ACE2 were significantly high among female hypertensives, while T allele of ACE2 was linked to male hypertensives. In the male population, alcohol was also identified as a potential risk factor. CONCLUSION: Among females, ACE I/D and ACE2 rs2106809 polymorphisms, while among males, ACE2 rs2106809 polymorphism and alcohol consumption are associated with essential hypertension in the study population.
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Patnaik et al. (2013) conducted a case-control in essential hypertension (n=520). ACE I/D and ACE2 rs2106809 polymorphisms vs. Normotensives was evaluated on Essential hypertension. The DD genotype of ACE and TT genotype of ACE2 were significantly associated with essential hypertension in females, while the T allele of ACE2 and alcohol consumption were associated in males.
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