What is the clinical evidence from this study?

Study design: Other. Population: Surgically induced pressure overload. Intervention: Cyclosporine (CsA) vs. Vehicle (TAB+Veh) or unbanded mice. Primary outcome: Cardiac hypertrophy (heart weight/body weight) (p=<0.05).

What question did this study set out to answer?

This study investigates whether cardiac hypertrophy is a necessary response to pressure overload in the heart.

June 20, 2000Circulation

Cardiac Hypertrophy Is Not a Required Compensatory Response to Short-Term Pressure Overload

Q: What are the key findings of this study?

Calcineurin blockade with cyclosporine completely inhibited cardiac hypertrophy in mice subjected to 5 weeks of pressure overload, maintaining normal LV size and systolic function.

Q: What question did this study set out to answer?

This study investigates whether cardiac hypertrophy is a necessary response to pressure overload in the heart.

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Why the study?

Does calcineurin inhibition with cyclosporine prevent cardiac hypertrophy and maintain ventricular function in mice with surgically induced pressure overload?

Population

Mice with surgically induced pressure overload via thoracic aortic banding (TAB)

Comparison

Calcineurin inhibition with cyclosporine (CsA) vs Banded mice injected with vehicle and unbanded…

Design

Preclinical

Follow-up

5 weeks

Key result

Calcineurin blockade with cyclosporine completely inhibited cardiac hypertrophy in mice subjected to 5 weeks of pressure overload, maintaining normal LV size and systolic function.

Authors

JHJoseph A. Hill MKMohsen Karimi WKWilliam Kutschke

Discussion

Member takes

Overview

Does not support clinical use of cyclosporine; challenges compensatory role of hypertrophy and leaves translation to humans open.

Key Points

This study investigates whether cardiac hypertrophy is a necessary response to pressure overload in the heart.
Mice underwent thoracic aortic banding (TAB) to induce pressure overload.
Calcineurin was inhibited using cyclosporine (CsA) to assess its role in hypertrophy.
Echocardiography was performed to evaluate ventricular size and function post-treatment.
CsA completely inhibited hypertrophy; heart mass in TAB+CsA group was 5.2 mg/g at 5 weeks compared to 8.3 mg/g in TAB+Veh (P<0.05).
Ventricular size and function remained normal; end-diastolic volume was 33 microL in TAB+CsA, 44 microL in TAB+Veh.
No difference in mortality rates between TAB+CsA and TAB+Veh, indicating no cardiovascular compromise.

Structured PICO

Does calcineurin inhibition with cyclosporine prevent cardiac hypertrophy and maintain ventricular function in mice with surgically induced pressure overload?

Population

Mice subjected to surgically induced pressure overload via thoracic aortic banding, followed for 5 weeks.

Intervention

Calcineurin inhibition with cyclosporine (CsA)

Comparator

Banded mice injected with vehicle (TAB+Veh) and unbanded mice

Outcome

In vivo parameters of ventricular volume and function using echocardiography, heart mass, and myocyte surface area at 5 weekssurrogate

Main Result

Absolute Event Rate: 5.2% vs 8.3%

p-value: p=<0.05

Calcineurin blockade with cyclosporine prevents left ventricular hypertrophy due to pressure overload in mice without compromising systolic function or survival, challenging the concept that hypertrophy is a required compensatory response.

Cite This Study

Hill et al. (2000) studied Surgically induced pressure overload. Cyclosporine (CsA) vs. Vehicle (TAB+Veh) or unbanded mice was evaluated on Cardiac hypertrophy (heart weight/body weight) (p=<0.05). Calcineurin blockade with cyclosporine completely inhibited cardiac hypertrophy in mice subjected to 5 weeks of pressure overload, maintaining normal LV size and systolic function.

synapsesocial.com/papers/6a2016e735281a23f90de884 https://doi.org/10.1161/01.cir.101.24.2863

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June 20, 2000Circulation

Cardiac Hypertrophy Is Not a Required Compensatory Response to Short-Term Pressure Overload

View Full Paper

Ask AI

Bookmark

Why the study?

Does calcineurin inhibition with cyclosporine prevent cardiac hypertrophy and maintain ventricular function in mice with surgically induced pressure overload?

Population

Mice with surgically induced pressure overload via thoracic aortic banding (TAB)

Comparison

Calcineurin inhibition with cyclosporine (CsA) vs Banded mice injected with vehicle and unbanded…

Design

Preclinical

Follow-up

5 weeks

Key result

Calcineurin blockade with cyclosporine completely inhibited cardiac hypertrophy in mice subjected to 5 weeks of pressure overload, maintaining normal LV size and systolic function.

Authors

JHJoseph A. Hill MKMohsen Karimi WKWilliam Kutschke

Discussion

Member takes

Overview

Does not support clinical use of cyclosporine; challenges compensatory role of hypertrophy and leaves translation to humans open.

Key Points

This study investigates whether cardiac hypertrophy is a necessary response to pressure overload in the heart.
Mice underwent thoracic aortic banding (TAB) to induce pressure overload.
Calcineurin was inhibited using cyclosporine (CsA) to assess its role in hypertrophy.
Echocardiography was performed to evaluate ventricular size and function post-treatment.
CsA completely inhibited hypertrophy; heart mass in TAB+CsA group was 5.2 mg/g at 5 weeks compared to 8.3 mg/g in TAB+Veh (P<0.05).
Ventricular size and function remained normal; end-diastolic volume was 33 microL in TAB+CsA, 44 microL in TAB+Veh.
No difference in mortality rates between TAB+CsA and TAB+Veh, indicating no cardiovascular compromise.

Structured PICO

Does calcineurin inhibition with cyclosporine prevent cardiac hypertrophy and maintain ventricular function in mice with surgically induced pressure overload?

Population

Mice subjected to surgically induced pressure overload via thoracic aortic banding, followed for 5 weeks.

Intervention

Calcineurin inhibition with cyclosporine (CsA)

Comparator

Banded mice injected with vehicle (TAB+Veh) and unbanded mice

Outcome

In vivo parameters of ventricular volume and function using echocardiography, heart mass, and myocyte surface area at 5 weekssurrogate

Main Result

Absolute Event Rate: 5.2% vs 8.3%

p-value: p=<0.05

Cite This Study

synapsesocial.com/papers/6a2016e735281a23f90de884 https://doi.org/10.1161/01.cir.101.24.2863

View Full Paper

Ask AI

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