Key result
La autoantigen bound specifically to the second half of the 5'-UTR of the BiP IRES and enhanced translation of BiP mRNA in both in vitro and in vivo assays.
Population
in vitro and in vivo assays for human BiP mRNA translation
Design
Preclinical
Authors
Loading...
Hypothesis-generating for La in cardiac ER stress responses; leaves open relevance to human disease or therapy.
La autoantigen enhances the IRES-dependent translation of BiP mRNA, suggesting a common mechanism between cellular and viral IRESs.
Yoon Ki Kim (2001) studied this question. La autoantigen was evaluated on Translation of BiP mRNA. La autoantigen bound specifically to the second half of the 5'-UTR of the BiP IRES and enhanced translation of BiP mRNA in both in vitro and in vivo assays.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: