Population
Hepatitis C virus, classical swine fever virus, and GB virus B internal ribosome entry site reporter RNA…
Comparison
Mutations including deletion of adenosine-rich… vs Unmodified reporter RNA constructs
Design
Preclinical
Authors
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Highlights structural constraints for IRES vectors; leaves open relevance to mammalian translation in vivo.
There is no absolute requirement for viral protein-coding sequence for HCV IRES-mediated translation, but an absence of stable RNA structure immediately downstream of the AUG initiator codon is required.
Rijnbrand et al. (2001) studied this question.
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