October 1, 2005Alcoholism Clinical and Experimental Research
Alcohol Consumption and Platelet Activation and Aggregation Among Women and Men: The Framingham Offspring Study
Key result
Alcohol consumption was inversely associated with platelet activation (p=0.007) and aggregation (p=0.008) in response to ADP among men, and with ADP-induced aggregation among women (p=0.04).
Why the study?
Does alcohol consumption reduce platelet activation and aggregation in adults free of cardiovascular disease?
Population
Adults free of cardiovascular disease enrolled in the Framingham Offspring Study
Design
Cross-sectional
Authors
Discussion
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Implication
May support mechanistic link to alcohol's cardiovascular associations; hypothesis-generating and should not change practice.
Study Design
Type
Cross-Sectional (n=2,013)
Structured PICO
Does alcohol consumption reduce platelet activation and aggregation in adults free of cardiovascular disease?
P
Population
2,013 adults free of cardiovascular disease enrolled in the Framingham Offspring Study.
E
Exposure
Alcohol consumption (assessed via standardized questionnaire)
O
Outcome
Platelet activation in response to 1 and 5 microm of adenosine diphosphate (ADP) with a P-selectin assay, and platelet aggregability in response to ADP, epinephrine, and collagensurrogate
Main Result
p-value: p=0.007
Alcohol consumption is inversely associated with platelet activation and aggregation, particularly in men, which may provide mechanistic insight into its association with cardiovascular event risk.
Cite This Study
Mukamal et al. (2005) conducted a cross-sectional in Free of cardiovascular disease (n=2,013). Alcohol consumption was evaluated on Platelet activation (P-selectin expression) and platelet aggregability (p=0.007). Alcohol consumption was inversely associated with platelet activation (p=0.007) and aggregation (p=0.008) in response to ADP among men, and with ADP-induced aggregation among women (p=0.04).