Key result
Alcoholism in males under 50 was associated with significantly reduced fibrinolytic activity compared to healthy controls (P=0.005), suggesting an increased thrombotic tendency.
Why the study?
Does alcoholism alter platelet aggregation and fibrinolytic activity in young males?
Population
29 alcoholic males under 50 years of age with no evidence of acute cerebrovascular disease
Comparison
Alcoholism (chronic alcohol consumption) vs Age-matched healthy nonalcoholic volunteers
Design
Case-control
Authors
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May signal heightened thrombotic risk in young male alcoholics; leaves open causal contribution to early stroke.
Case-Control
Does alcoholism alter platelet aggregation and fibrinolytic activity in young males?
p-value: p=0.005
Young alcoholic males demonstrate reduced fibrinolytic activity, suggesting a prothrombotic state that may increase early stroke risk.
Lee et al. (2009) conducted a case-control in Alcoholism. Alcoholism vs. Healthy nonalcoholic volunteers was evaluated on Fibrinolytic activity and platelet aggregation (p=0.005). Alcoholism in males under 50 was associated with significantly reduced fibrinolytic activity compared to healthy controls (P=0.005), suggesting an increased thrombotic tendency.
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