Key result
Platelets from alcoholics undergoing detoxification were more sensitive to ADP and synthesized up to triple the amount of TXB2 compared to healthy nonalcoholic donors.
Why the study?
Does alcohol abuse and detoxification increase platelet aggregation and thromboxane B2 formation compared to healthy controls?
Population
20 men (10 healthy men and 10 male alcoholics without anemia or thrombo-embolic disease)
Comparison
Alcohol abuse and subsequent 2-week detoxification vs Healthy nonalcoholic men
Design
Case-control
Follow-up
2 weeks
Authors
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May heighten thrombotic risk during alcohol detoxification; leaves open causal role and need for prospective trials.
Observational (n=20)
Does alcohol abuse and detoxification increase platelet aggregation and thromboxane B2 formation compared to healthy controls?
Alcoholics undergoing detoxification show increased platelet sensitivity and thromboxane B2 formation, which may contribute to increased thrombotic risk.
Hillbom et al. (2009) conducted an observational in Ethanol abuse (n=20). Ethanol abuse vs. Healthy nonalcoholic men was evaluated on Thromboxane B2 (TXB2) formation during ADP-induced platelet aggregation. Platelets from alcoholics undergoing detoxification were more sensitive to ADP and synthesized up to triple the amount of TXB2 compared to healthy nonalcoholic donors.
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