Why the study?
Does chronic alcohol consumption alter platelet function and prostaglandin metabolism?
Population
112 individuals (88 chronic alcoholics and 24 healthy controls)
Comparison
Chronic alcohol consumption (exposure) vs Healthy controls
Design
Cohort
Follow-up
4 weeks of abstinence
Authors
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Elevated TxB2 in chronic alcoholics may signal altered platelet function; hypothesis-generating for hemostatic effects and needs prospective confirmation.
Does chronic alcohol consumption alter platelet function and prostaglandin metabolism?
Chronic alcohol consumption alters platelet thromboxane metabolism and increases platelet aggregation, which normalizes after 4 weeks of abstinence.
Arm et al. (1986) studied this question.