Key result
Shear-induced PDGF gene expression in human umbilical vein endothelial cells is mainly mediated by protein kinase C activation and requires intracellular calcium and G proteins.
Population
Human umbilical vein endothelial cells (HUVEC)
Comparison
Shear stress in the presence of various… vs Shear stress without inhibitors
Design
Preclinical
Authors
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Highlights PKC as key mediator in endothelial shear response; leaves open clinical translation to vascular therapies.
Shear-induced PDGF gene expression in human endothelial cells is primarily mediated by protein kinase C activation and requires intracellular calcium.
Hsieh et al. (1992) studied this question. Shear stress was evaluated on PDGF gene expression. Shear-induced PDGF gene expression in human umbilical vein endothelial cells is mainly mediated by protein kinase C activation and requires intracellular calcium and G proteins.
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