August 10, 2007AJP Heart and Circulatory Physiology
Revisiting methods for assessing and comparing left ventricular diastolic stiffness: impact of relaxation, external forces, hypertrophy, and comparators
Key result
The relaxation-corrected single beat method showed excellent correlation (r = 0.97) and agreement with the multiple-beat method for deriving EDV(10-30) to construct the diastolic PVR.
Why the study?
Does the relaxation-corrected single beat method accurately estimate left ventricular diastolic stiffness compared to the multiple-beat method in a canine model?
Population
26 young normal or old hypertensive dogs (n=14 with pericardium intact, n=12 with pericardium absent)
Comparison
Relaxation-corrected single beat method for… vs Multiple-beat (MB) (vena cava occlusion) method
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Offers a simplified, volume-independent approach to assess left ventricular diastolic stiffness; leaves open whether this single.
Structured PICO
Does the relaxation-corrected single beat method accurately estimate left ventricular diastolic stiffness compared to the multiple-beat method in a canine model?
P
Population
26 young normal or old hypertensive dogs studied to compare methods for constructing the diastolic pressure-volume relationship.
I
Intervention
Relaxation-corrected single beat (RC-SB) method for constructing the diastolic pressure-volume relationship (PVR)
C
Comparator
Multiple-beat (MB) (vena cava occlusion) method
O
Outcome
Correlation and agreement of derived stiffness indexes (beta, alpha, and EDV at 10, 20, or 30 mmHg) between RC-SB and MB methodssurrogate
Main Result
Effect estimate: r = 0.97
The relaxation-corrected single beat method can substitute for the multiple-beat technique in constructing the diastolic pressure-volume relationship in the absence of acute volume expansion, best assessed using EDV(10-30).
Cite This Study
Jaber et al. (2007) studied young normal or old hypertensive dogs (n=26). Relaxation-corrected single beat (RC-SB) method vs. Multiple-beat (MB) method was evaluated on EDV(10-30) derived from RC-SB vs MB PVR (r = 0.97). The relaxation-corrected single beat method showed excellent correlation (r = 0.97) and agreement with the multiple-beat method for deriving EDV(10-30) to construct the diastolic PVR.