Key result
Verapamil lowered blood pressure by an average of 20/16 mm Hg compared to 9/11 mm Hg with propranolol, with significant differences only for sitting systolic blood pressure.
Why the study?
Does verapamil reduce blood pressure compared to propranolol in subjects with mild to moderate essential hypertension?
Population
24 subjects with mild to moderate essential hypertension
Comparison
Verapamil 240 to 480 mg daily vs Propranolol 120 to 360 mg daily
Design
RCT, randomized, double-blind
Follow-up
9 weeks
Authors
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Verapamil offers comparable or greater BP reduction than propranolol in mild-moderate hypertension; confirms its role as an alternative in this RCT population.
RCT (n=24)
Double-blind
parallel
Does verapamil reduce blood pressure compared to propranolol in subjects with mild to moderate essential hypertension?
Verapamil is an effective antihypertensive agent for mild to moderate essential hypertension, providing blood pressure reductions comparable to or greater than propranolol.
Halperin et al. (1984) conducted an RCT in mild to moderate essential hypertension (n=24). Verapamil vs. Propranolol (120 to 360 mg%) was evaluated on blood pressure reduction. Verapamil lowered blood pressure by an average of 20/16 mm Hg compared to 9/11 mm Hg with propranolol, with significant differences only for sitting systolic blood pressure.
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