What question did this study set out to answer?

This research aims to explore how treadmill training impacts skeletal muscle metabolism and cardiac function in myopathic hamsters compared to normal hamsters.

December 1, 1977Journal of Applied Physiology

Muscle metabolism and cardiac function of the myopathic hamster following training

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Why the study?

Does exercise training improve skeletal muscle metabolism and cardiac function in myopathic hamsters?

Population

Normal and myopathic hamsters (BIO 14.6 strain)

Comparison

18 weeks of treadmill running vs Nontrained controls

Design

Preclinical

Follow-up

18 weeks

Authors

WSW. L. SembrowichUniversity of Lethbridge MKMark B. KnudsonReShape Lifesciences (United States)PGP. D. GollnickWashington State University

Discussion

Member takes

Implication

Tolerated with partial contractility preservation in myopathic hamsters; hypothesis-generating for exercise in cardiomyopathy, pending clinical validation.

Key Points

This research aims to explore how treadmill training impacts skeletal muscle metabolism and cardiac function in myopathic hamsters compared to normal hamsters.
BIO 14.6 myopathic hamsters underwent 18 weeks of treadmill running at 18 m/min for 40 minutes, 5 days per week.
Skeletal muscle and cardiac function were assessed through enzymatic activity and left ventricular pressure curves.
Evaluated markers included succinate dehydrogenase activity, ATP, CP, and glycogen levels.
Trained myopathic hamsters exhibited increased succinate dehydrogenase activity in the soleus muscle.
Cardiac contractility, measured as (dP/dt)/kP, was improved in trained myopathic hamsters compared to nontrained controls but was still lower than normal hamsters.
Trained myopathic hamsters had the lowest ATP, CP, and glycogen levels among the groups studied.

Structured PICO

Does exercise training improve skeletal muscle metabolism and cardiac function in myopathic hamsters?

Population

Normal and myopathic hamsters (BIO 14.6 strain)

Intervention

18 weeks of treadmill running (exercise training, up to 18 m/min for 40 min, 5 days/wk for myopathic hamsters)

Comparator

Nontrained controls (normal and myopathic hamsters)

Outcome

Skeletal muscle metabolism and myocardial function (cardiac contractility measured from left ventricular pressure curves)surrogate

Exercise training is tolerated by myopathic hamsters and may partially preserve cardiac contractility, despite reductions in muscle energy stores.

Cite This Study

Sembrowich et al. (1977) studied this question.

synapsesocial.com/papers/6a2047ee188a18290d882e47 https://doi.org/10.1152/jappl.1977.43.6.936

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Implication

Tolerated with partial contractility preservation in myopathic hamsters; hypothesis-generating for exercise in cardiomyopathy, pending clinical validation.

Muscle metabolism and cardiac function of the myopathic hamster following training

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Muscle metabolism and cardiac function of the myopathic hamster following training

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider