Key result
A 26-year-old female with giant cell myocarditis suffered sudden cardiac death from refractory ventricular arrhythmias despite immunosuppressive therapy and an implantable defibrillator.
Case Report (n=1)
Giant cell myocarditis is a rare, rapidly progressive disease requiring high clinical suspicion, early endomyocardial biopsy, and aggressive arrhythmia management.
Documents sudden death despite immunosuppression and ICD in giant cell myocarditis; hypothesis-generating for optimal management strategies.
Giant cell myocarditis is a rare type of rapidly progressive myocarditis. We present a dramatic case of giant cell myocarditis in a young female with an initial presentation of acute heart failure. Her clinical course was complicated with recurrent cardiac arrhythmias, specifically non-sustained ventricular tachycardia, for which a dual chamber automated implantable cardioverter defibrillator (AICD) was implanted. Eventually, she presented with cardiac arrest despite being on antiarrhythmic medication and an implantable defibrillator. In the right clinical context, such as an acute presentation of unexplained new-onset heart failure and arrhythmias in a young patient, it is very important to maintain high suspicion of such a rare disease.
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Ghaly et al. (2020) conducted a case report in Giant cell myocarditis (n=1). Immunosuppressive therapy and AICD was evaluated. A 26-year-old female with giant cell myocarditis suffered sudden cardiac death from refractory ventricular arrhythmias despite immunosuppressive therapy and an implantable defibrillator.
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