Key result
Taking antihypertensive medication at bedtime compared to upon waking significantly reduced the risk of major cardiovascular events (HR 0.55).
Why the study?
Does taking antihypertensive medication at bedtime reduce cardiovascular events compared to morning administration in adults with hypertension?
RCT (n=19,084)
Open-label, blinded endpoint
1:1
Yes
Does taking antihypertensive medication at bedtime reduce cardiovascular events compared to morning administration in adults with hypertension?
Hazard Ratio: 0.55 (95% CI 0.5–0.61)
p-value: p=<.001
Administering antihypertensive medications at bedtime rather than upon waking significantly reduces the risk of major cardiovascular events in primary care patients.
Is it better to take that antihypertensive at night? A large RCT in a primary care setting comparing bedtime to upon-waking administration of antihypertensives answers the question.
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Dickman (2020) conducted an RCT in Hypertension (n=19,084). Antihypertensive medication at bedtime vs. Antihypertensive medication upon waking was evaluated on Composite of CVD events including new-onset myocardial infarction, coronary revascularization, heart failure, ischemic stroke, hemorrhagic stroke, and CVD death (HR 0.55, 95% CI 0.50-0.61, p=<.001). Taking antihypertensive medication at bedtime compared to upon waking significantly reduced the risk of major cardiovascular events (HR 0.55).
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