Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 1, 1994Endocrinology

Short-term desensitization of the angiotensin II receptor of bovine adrenal glomerulosa cells corresponds to a shift from a high to a low affinity state.

View Full Paper
Ask AI
Bookmark
Share

Population

Primary culture of bovine adrenal glomerulosa (BAG) cells

Comparison

Short exposure to Angiotensin II vs Control cells without Angiotensin II…

Design

Preclinical

Follow-up

up to 60 minutes

Authors

GBGuylain BoulayUniversité de SherbrookeLCLouise ChrétienÉcole Nationale Supérieure d'Architecture de NantesDRDarren E. RichardCentre hospitalier universitaire de Québec

Discussion

Loading...

Member takes

Implication

Hypothesis-generating for Ang II-induced AT1 desensitization in adrenal cells; leaves open human translation and clinical relevance.

Structured PICO

P
Population
Primary culture of bovine adrenal glomerulosa (BAG) cells
I
Intervention
Short exposure to Angiotensin II (e.g., 30 min with 30 nM or 10 nM Ang II)
C
Comparator
Control cells without Angiotensin II pretreatment, or co-treatment with selective antagonists (DuP-753, PD-123319) or inhibitors (staurosporine, R24571)
O
Outcome
[125I]Ang II binding capacity and receptor affinity statessurrogate

Short-term exposure to Angiotensin II causes reversible desensitization of the AT1 receptor in bovine adrenal glomerulosa cells by shifting it from a high to a low affinity state, likely due to uncoupling from its G protein.

Cite This Study

Boulay et al. (1994) studied this question.

synapsesocial.com/papers/6a208704ca5c5b2ddfa5ed7ehttps://doi.org/10.1210/endo.135.5.7956936
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family1989 · 452 citations
  2. 2Control of Aldosterone Secretion1979 · 140 citations
  3. 3Agonist-induced down-regulation of the angiotensin II receptor in primary cultures of rat hepatocytes.1988 · 40 citations
  4. 4Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor.1990 · 106 citations