Key result
His-bundle pacing in patients with LBBB-mediated cardiomyopathy significantly improved average left ventricular ejection fraction from 25% to 50% (p=0.0001).
Why the study?
Chronic LBBB can lead to LBBB-mediated cardiomyopathy from LV dyssynchrony, and the feasibility of His-bundle pacing for CRT in these patients required assessment.
Does His-bundle pacing improve echocardiographic parameters and symptoms in patients with LBBB-mediated cardiomyopathy?
Cohort (n=7)
Yes
Does His-bundle pacing improve echocardiographic parameters and symptoms in patients with LBBB-mediated cardiomyopathy?
Absolute Event Rate: 50% vs 25%
p-value: p=0.0001
His-bundle pacing significantly improves left ventricular ejection fraction, dimensions, and symptoms in patients with LBBB-mediated cardiomyopathy.
No takes yet. Share an insight, caveat, or question.
May improve LVEF in LBBB cardiomyopathy; hypothesis-generating and requires randomized confirmation before practice change.
Singh et al. (2020) conducted a cohort in LBBB-mediated cardiomyopathy (n=7). His-bundle pacing vs. Baseline (pre-intervention) was evaluated on Left ventricular ejection fraction (p=0.0001). His-bundle pacing in patients with LBBB-mediated cardiomyopathy significantly improved average left ventricular ejection fraction from 25% to 50% (p=0.0001).
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