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This research aims to understand how vasodilating drugs affect renin release and the role of beta-adrenergic inhibition.

July 1, 1973Circulation ResearchOpen Access

Adrenergic Component of Renin Release Induced by Vasodilating Antihypertensive Drugs in the Rat

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This research aims to understand how vasodilating drugs affect renin release and the role of beta-adrenergic inhibition.
Characterized renin release induced by minoxidil and hydralazine in rats by dosage and timing.
Measured propranolol's effect on renin release in correlation with serum propranolol levels.
Minoxidil and hydralazine increased serum renin activity by sevenfold at a dose of 1.0 mg/kg.
Propranolol administration impaired the induced renin release, with effective plasma levels starting at 50 ng/ml.

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Attenuates vasodilator-induced renin release by propranolol in rats; leaves open translation to human hypertension therapy.

Pettinger et al. (1973) studied this question.

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