What question did this study set out to answer?

This study aims to investigate the baroreflex function in patients with a specific genetic form of hypertension and neurovascular contact.

November 21, 2000Circulation

Severely Impaired Baroreflex-Buffering in Patients With Monogenic Hypertension and Neurovascular Contact

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Why the study?

How do autonomic function and baroreflex buffering differ in patients with monogenic hypertension and neurovascular contact compared to control subjects?

Population

5 patients with monogenic hypertension and neurovascular contact of the brain stem, alongside control subjects

Comparison

Detailed autonomic function tests including… vs Control subjects undergoing the same autonomic…

Design

Case-control

Authors

JJJens JordanGeneral Cardiology HTHakan R. TokaState College of Florida Manatee-Sarasota KHKarsten HeusserVascular Medicine

Discussion

Member takes

Implication

Impaired baroreflex buffering is associated with monogenic hypertension; leaves open broader applicability and therapeutic targeting.

Key Points

This study aims to investigate the baroreflex function in patients with a specific genetic form of hypertension and neurovascular contact.
Conducted detailed autonomic function tests in 5 patients aged 18 to 34 years with monogenic hypertension.
Measured blood pressure during complete ganglionic blockade and assessed levels of plasma vasopressin.
Evaluated responses to cold pressor testing, hand-grip testing, and upright posture.
In patients, blood pressure was significantly elevated (134±4.9/82±4.1 mm Hg) during ganglionic blockade compared to controls (90±6/49±2.4 mm Hg).
Plasma vasopressin increased less than 2-fold in patients compared to a 24-fold increase in control subjects during blockade.
Increased systolic blood pressure in patients was achieved with significantly lower doses of phenylephrine both before and during ganglionic blockade.

Structured PICO

How do autonomic function and baroreflex buffering differ in patients with monogenic hypertension and neurovascular contact compared to control subjects?

Population

5 patients with monogenic hypertension (18 to 34 years old) and neurovascular contact of the brain stem, alongside control subjects

Intervention

Detailed autonomic function tests including complete ganglionic blockade, cold pressor testing, hand-grip testing, upright posture, and phenylephrine administration

Comparator

Control subjects undergoing the same autonomic function tests

Outcome

Blood pressure, plasma vasopressin concentration, muscle sympathetic nerve activity, and phenylephrine dose responsesurrogate

Patients with monogenic hypertension and neurovascular contact exhibit severely impaired baroreflex buffering and baroreflex-mediated vasopressin release, leading to excessive blood pressure responses to sympathetic stimuli.

Cite This Study

Jordan et al. (2000) studied this question.

synapsesocial.com/papers/6a214dfaf6aa648d3a57dc47 https://doi.org/10.1161/01.cir.102.21.2611

Topics

Hypertension management

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Severely Impaired Baroreflex-Buffering in Patients With Monogenic Hypertension and Neurovascular Contact

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Severely Impaired Baroreflex-Buffering in Patients With Monogenic Hypertension and Neurovascular Contact

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider