Why the study?
Does baroreflex buffering affect the sensitivity to vasoactive drugs in patients with varying degrees of autonomic function?
Population
Patients with idiopathic orthostatic intolerance, patients with essential hypertension, patients with…
Comparison
Phenylephrine and nitroprusside infusions vs Control subjects
Design
Cross-sectional
Authors
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Baroreflex buffering may alter vasoactive drug sensitivity; hypothesis-generating for autonomic phenotyping in hypertension but should not yet change practice.
Does baroreflex buffering affect the sensitivity to vasoactive drugs in patients with varying degrees of autonomic function?
Baroreflex blood pressure buffering significantly affects the sensitivity to vasoactive drugs, with even moderate changes in baroreflex function having a substantial impact.
Jordan et al. (2002) studied this question.
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