Why the study?
Does the sympathetic discharge accompanying hemorrhagic shock modify the release of norepinephrine by tyramine in dogs?
Does the sympathetic discharge accompanying hemorrhagic shock modify the release of norepinephrine by tyramine in dogs?
Prolonged hypotension diminishes responsiveness to tyramine due to decreased release of norepinephrine, likely from the depletion of the specific norepinephrine store releasable by tyramine.
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Prolonged hypotension may deplete tyramine-releasable norepinephrine stores in canine shock; leaves open clinical translation to human vasopressor use.
Harrison et al. (1964) studied this question.
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